Orphan Nuclear Receptors: From Gene to Function*
نویسندگان
چکیده
منابع مشابه
Orphan nuclear receptors in drug discovery.
Orphan nuclear receptors provide a unique resource for uncovering novel regulatory systems that impact human health and also provide drug targets for a variety of human diseases. Ligands of nuclear receptors have been used in several important therapeutic areas, such as breast cancers, skin disorders and diabetes. Orphan nuclear receptors, therefore, represent a tremendous opportunity in unders...
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Enterocytes protect themselves from the detergent actions of intracellular bile acids by expressing the ileal bile acid binding protein (encoded by the IBABP gene), which facilitates the movement of the detergents across the cell and their secretion into the portal circulation. Over the last three decades, much progress has been When they reach the liver, the bile acids are taken up made in und...
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Orphan nuclear receptors such as germ cell nuclear factor (GCNF), steroidogenic factor 1 (SF-1) and liver receptor homolog-1 (LRH-1), are emerging as important ovarian factors in regulating female reproduction. Within the ovary, GCNF (NR6A1) expression is restricted to the oocyte, while SF-1 (NR5A1) is expressed only in the somatic cells, such as granulosa, thecal and luteal cells, and intersti...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 1999
ISSN: 0163-769X,1945-7189
DOI: 10.1210/edrv.20.5.0378